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Overview

Lysine methacrylation (Kmea) is a new type of posttranslational modification and a structural isomer of crotonyllysine (Kcr). Kmea is a reversible PTM, which is related by HAT1 as a methacryltransferase and SIRT2 as a demethacrylase. The discovery of Kmea provides new insights into the interplay between metabolism and epigenetic regulation.

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