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SUMOylation is a reversible post-translational modification that regulates protein function through the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to specific lysine residues in proteins. This process is mediated by SUMO-related enzymes and regulates diverse cellular process, including protein stability, nuclear transport, transcription, DNA repair, and stress response. Emerging studies have revealed the critical role of SUMOylation in maintaining cellular homeostasis and regulating complex biological processes, making it an important target for understanding protein regulation and cellular function.