U-Blot® CENP-A (phospho Ser7) Polyclonal Antibody

Name: U-Blot® CENP-A (phospho Ser7) Polyclonal Antibody
SKU: WP10201
Availability: InStock

$288.00

Size:50μL

SKU: WP10201-50

Catalog No.: WP10201

Specification: 50μL/100μL

Stock: In stock

U-Blot® CENP-A (phospho Ser7) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015],

Product Overview

Catalog No.: WP10201
SKU: WP10201-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: CENP-A
Reactivity: Human,Rat,Mouse,
Application: IF,ELISA
MW(Calculated): 16kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications;
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Centromeric Protein A around the phosphorylation site of Ser7. AA range:1-50
Sequence: --
Specificity: Phospho-CENP-A (S7) Polyclonal Antibody detects endogenous levels of CENP-A protein only when phosphorylated at S7.
Gene Name: CENPA
Protein Name: Histone H3-like centromeric protein A
Other Name: CENPA;Histone H3-like centromeric protein A;Centromere autoantigen A;Centromere protein A;CENP-A
Organism-1: Human
Gene ID-1: 1058
SwissProt-1: P49450
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: O35216
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Chromosome, centromere, kinetochore . Chromosome, centromere . Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658). .