Overview
Organoid models recapitulate a wide range of biological characteristics associated with human development, disease initiation, tissue homeostasis and tissue repair, yielding abundant promising candidate therapeutic targets. We supply a full portfolio of organoid research reagents alongside standardized culture systems, empowering cell biologists to refine culture protocols and establish organoid models featuring high viability as well as uniform and stable phenotypes.
Subcategories
Organoid Models- physiological organoidsOrganoid Models- physiological organoids>> View productsOrganoid Models- pathological organoidsOrganoid Models- pathological organoidsTumor initiation and progression involve sustained, complex dynamic crosstalk between malignantly transformed cells and the tumor microenvironment (TME). Immunotherapies targeting the immune TME have been validated in numerous clinical trials; however, therapeutic responses vary drastically across different tumor histotypes, and are commonly hampered by transient efficacy, prominent inter-individual heterogeneity and widespread drug resistance. Accordingly, high-fidelity experimental models that faithfully reconstruct patient-specific tumor immune microenvironments and recapitulate tumor biological traits as well as immunotherapeutic responses can greatly streamline patient stratification, target discovery and mechanistic research on drug resistance for immuno-oncology agents. Tumor organoid models fully retain the core immune signatures of the TME, holding broad application prospects in tumor immunology research, new drug development and precision medicine.
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