Recombinant Human/Mouse/Rat GDF11/BMP11 Protein

Recombinant Human/Mouse/Rat GDF11/BMP11 Protein
Recombinant Human/Mouse/Rat GDF11/BMP11 Protein
$210.00
Size:10μg
SKU: PR00102-10μg

Catalog No.: PR00102

Specification: 10μg/50μg/500μg/1mg

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background:Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.

Product Overview

Catalog No.
PR00102
SKU
PR00102-10μg
Category
TGF-beta Superfamily
Product Type
Other
Size
10μg/50μg/500μg/1mg
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Research Use Only
Yes

Additional Specifications

Molecule
BMP11/GDF11
Background
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.
Species
Human/Mouse/Rat
Source
HEK293 Cells
Tags
Tag free
Accession
O95390
KnownAs
Growth/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11
Protein Length
Asn299-Ser407
Predicted Molecular Mass
12.5 KDa
N-terminal Sequence
--
SDS-PAGE
13-20 KDa, reducing conditions
Endotoxin
<1 EU/µg as determined by LAL test.
Concentration
--
Purity-SDS-PAGE
>95% as determined by SDS-PAGE.
Purity-SEC-HPLC
--
Activity
--
Form
Liquid
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4.
Shipping
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Reconstitution
--

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

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Keywords:TGF-beta Superfamily