- PackSize
- 50ug/100ug
- Target
- Vimentin
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Human
- Isotype
- IgG1-nd
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- Vimentin, VIM
- Species
- --
- Gene ID-1
- P08670
- Uniprot
- --
- Background
- Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody against vimentin expressed on the surface of virus-infected cells, with broad-spectrum antiviral activity and anti-inflammatory effects against virus-induced inflammation. Burfiralimab can be used in severe COVID-19 studies.<br>• Roles of vimentin in health and disease., PMID:35487686<br/>• Spatial single-cell protein landscape reveals vimentin<sup>high</sup> macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma., PMID:39327501<br/>• Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin., PMID:37641404<br/>• FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression., PMID:37915048<br/>• Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier., PMID:35433510<br/>• Vimentin on the move: new developments in cell migration., PMID:30505430<br/>• Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma., PMID:38901494<br/>• Vimentin as a universal receptor for pseudorabies virus infection in pig and human cells., PMID:39549807<br/>• PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells., PMID:39294765<br/>• Vimentin, colon cancer progression and resistance to butyrate and other HDACis., PMID:27072512<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --