U-Blot® Recombinant CD62L (VF0348) Fc-Fused Nanobody

U-Blot® Recombinant CD62L (VF0348) Fc-Fused Nanobody
U-Blot® Recombinant CD62L (VF0348) Fc-Fused Nanobody
$365.00
Size:100μL
SKU: WN0430

Specification: 100μL

Stock: In stock

U-Blot® Recombinant CD62L (VF0348) Fc-Fused Nanobody Learn more

Product information

Background:This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus.This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified inThis gene. [provided by RefSeq, Aug 2010]

Product Overview

Catalog No.
WN0430
SKU
WN0430
Category
Nanobodies
Product Type
Other
Size
100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Research Use Only
Yes

Additional Specifications

Target
CD4
Reactivity
Human
Application
ELISA
MW(Calculated)
--
MW(Observed)
--
Host Species
Camel
Isotype
--
Conjugate/Modification
Unmodified
Modification site
--
Recommended Dilution Ratio
ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
Form
Phosphate-buffered solution
Source
Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification
Recombinant Expression and Affinity purified
Purity
--
storageCondition
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration
Please check the information on the tube
Clonality
Monoclonal
Clone No.
PN0618
Immunogen
Purified recombinant Human CD4
Sequence
--
Specificity
This recombinant monoclonal antibody can detects endogenous levels of CD4 protein.
Gene Name
CD4
Protein Name
L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Other Name
TQ1;LAM1;LEU8;LNHR;LSEL;CD62L;LYAM1;PLNHR;LECAM1;L-selectin;LECAM-1;SELL;LAM-1;TQ-1;MEL-14;CD62L nanobody;
Organism-1
Human
Gene ID-1
920
SwissProt-1
P01730
Organism-2
--
Gene ID-2
--
SwissProt-2
--
Organism-3
--
Gene ID-3
--
SwissProt-3
--
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
06

Contact Support

Emailinfo@ucallmlabs.com

Phone+(1)-866-986-9598

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HoursMonday-Friday 09:00-18:00 CST

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Keywords:Nanobodies