U-Blot® HAND1 (phospho Ser98) Polyclonal Antibody

Name: U-Blot® HAND1 (phospho Ser98) Polyclonal Antibody
SKU: WP10028
Availability: InStock

$288.00

Size:50μL

SKU: WP10028-50

Catalog No.: WP10028

Specification: 50μL/100μL

Stock: In stock

U-Blot® HAND1 (phospho Ser98) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10028
SKU: WP10028-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: HAND1
Reactivity: Human,Mouse,Rat
Application: IHC,IF,ELISA
MW(Calculated): 24kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human HAND1 around the phosphorylation site of Ser98. AA range:71-120
Sequence: --
Specificity: Phospho-HAND1 (S98) Polyclonal Antibody detects endogenous levels of HAND1 protein only when phosphorylated at S98.
Gene Name: HAND1
Protein Name: Heart- and neural crest derivatives-expressed protein 1
Other Name: HAND1;BHLHA27;EHAND;Heart- and neural crest derivatives-expressed protein 1;Class A basic helix-loop-helix protein 27;bHLHa27;Extraembryonic tissues;heart, autonomic nervous system and neural crest derivatives-expressed protein 1;eH
Organism-1: Human
Gene ID-1: 9421
SwissProt-1: O96004
Organism-2: Mouse
Gene ID-2: 15110
SwissProt-2: Q64279
Organism-3: Rat
Gene ID-3: 59112
SwissProt-3: P97832
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). .