U-Blot® KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody

Name: U-Blot® KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody
SKU: WP10036
Availability: InStock

$288.00

Size:50μL

SKU: WP10036-50

Catalog No.: WP10036

Specification: 50μL/100μL

Stock: In stock

U-Blot® KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10036
SKU: WP10036-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: KCNQ2/3/4/5
Reactivity: Human,Mouse,Rat
Application: WB,IHC,IF,ELISA
MW(Calculated): 97kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240
Sequence: --
Specificity: Phospho-KCNQ2/3/4/5 (T217/246/223/251) Polyclonal Antibody detects endogenous levels of KCNQ2/3/4/5 protein only when phosphorylated at T217/246/223/251.
Gene Name: KCNQ2
Protein Name: Potassium voltage-gated channel subfamily KQT member 2
Other Name: KCNQ2;Potassium voltage-gated channel subfamily KQT member 2;KQT-like 2;Neuroblastoma-specific potassium channel subunit alpha KvLQT2;Voltage-gated potassium channel subunit Kv7.2;KCNQ3;Potassium voltage-gated channel subfamily KQT me
Organism-1: Human
Gene ID-1: 3785;3786;9132;56479
SwissProt-1: O43526;O43525;P56696;Q9NR82
Organism-2: Mouse
Gene ID-2: 16536;110862;60613;226922
SwissProt-2: --
Organism-3: Rat
Gene ID-3: 170848;29682
SwissProt-3: O88943;O88944;Q9JK96
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Multi-pass membrane protein .