U-Blot® Bax (phospho Thr167) Polyclonal Antibody

Name: U-Blot® Bax (phospho Thr167) Polyclonal Antibody
SKU: WP10198
Availability: InStock

$288.00

Size:50μL

SKU: WP10198-50

Catalog No.: WP10198

Specification: 50μL/100μL

Stock: In stock

U-Blot® Bax (phospho Thr167) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.

Product Overview

Catalog No.: WP10198
SKU: WP10198-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Bax
Reactivity: Human,Mouse,Rat
Application: IF,ELISA
MW(Calculated): 21kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications;
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Bax around the phosphorylation site of Thr167. AA range:133-182
Sequence: --
Specificity: Phospho-Bax (T167) Polyclonal Antibody detects endogenous levels of Bax protein only when phosphorylated at T167.
Gene Name: BAX
Protein Name: Apoptosis regulator BAX
Other Name: BAX;BCL2L4;Apoptosis regulator BAX;Bcl-2-like protein 4;Bcl2-L-4
Organism-1: Human
Gene ID-1: 581
SwissProt-1: Q07812
Organism-2: Mouse
Gene ID-2: 12028
SwissProt-2: Q07813
Organism-3: Rat
Gene ID-3: --
SwissProt-3: Q63690
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: [Isoform Alpha]: Mitochondrion outer membrane ; Single-pass membrane protein . Cytoplasm . Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. Upon Sendai virus infection, recruited to the mitochondrion through interaction with IRF3 (PubMed:25609812). .; [Isoform Beta]: Cytoplasm.; [Isoform Gamma]: Cytoplasm.; [Isoform Delta]: Cytoplasm .