U-Blot® Stathmin Rabbit mAb

U-Blot® Stathmin Rabbit mAb
U-Blot® Stathmin Rabbit mAb
$268.00
Size:50μL
SKU: WR4992-50

Catalog No.: WR4992

Specification: 50μL/100μL

Stock: In stock

U-Blot® Stathmin Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],

Product Overview

Catalog No.
WR4992
SKU
WR4992-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
Stathmin 1
Reactivity
Human,Mouse,Rat
Application
WB,IHC,IF,IP,ELISA
MW(Calculated)
17kD
MW(Observed)
17kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Unmodified
Modification site
--
Recommended Dilution Ratio
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1224R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
STMN1
Protein Name
Stathmin
Other Name
STMN1;C1orf215;LAP18;OP18;Stathmin;Leukemia-associated phosphoprotein p18;Metablastin;Oncoprotein 18;Op18;Phosphoprotein p19;pp19;Prosolin;Protein Pr22;pp17
Organism-1
Human
Gene ID-1
3925
SwissProt-1
P16949
Organism-2
Mouse
Gene ID-2
16765
SwissProt-2
P54227
Organism-3
Rat
Gene ID-3
29332
SwissProt-3
P13668
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Disease:Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.,Function:Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.,PTM:Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.,similarity:Belongs to the stathmin family.,subunit:Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.,tissue specificity:Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

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Keywords:Rabbit mAbs