U-Blot® HDAC5 (Phospho Ser498) Rabbit mAb

U-Blot® HDAC5 (Phospho Ser498) Rabbit mAb
U-Blot® HDAC5 (Phospho Ser498) Rabbit mAb
$288.00
Size:50μL
SKU: WR5205-50

Catalog No.: WR5205

Specification: 50μL/100μL

Stock: In stock

U-Blot® HDAC5 (Phospho Ser498) Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.
WR5205
SKU
WR5205-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
HDAC5
Reactivity
Human,Mouse,Rat
Application
WB,IF,ELISA
MW(Calculated)
122kD
MW(Observed)
130kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Phospho
Modification site
--
Recommended Dilution Ratio
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1439R
Immunogen
--
Sequence
--
Specificity
HDAC5 (Phospho Ser498) Antibody detects endogenous levels of HDAC5 protein only when phosphorylated at S498.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TQsSP
Gene Name
HDAC5
Protein Name
Histone deacetylase 5
Other Name
HDAC5;KIAA0600;Histone deacetylase 5;HD5;Antigen NY-CO-9
Organism-1
Human
Gene ID-1
10014
SwissProt-1
Q9UQL6
Organism-2
Mouse
Gene ID-2
--
SwissProt-2
Q9Z2V6
Organism-3
--
Gene ID-3
--
SwissProt-3
--
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

Emailinfo@ucallmlabs.com

Phone+(1)-866-986-9598

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HoursMonday-Friday 09:00-18:00 CST

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Keywords:Rabbit mAbs