
Sku: WT8642

Catalog No.: WT8606
Specification: 100μL/300μL
Stock: In stock
Product details, specifications, documents, and related products are available from the catalog record. Learn more
Background: H3T6 phosphorylation exerts critical regulatory functions during mitosis. This modification counteracts adjacent H3K4me2/me3‑mediated chromatin recognition, prevents aberrant reading of methylation marks upon chromosome condensation, and ensures proper chromosome compaction and segregation in M‑phase. H3T6p is dynamically regulated throughout cell cycle: signal peaks in mitotic cells and diminishes after mitotic exit. Mis‑regulation of H3T6 phosphorylation disturbs mitotic progression, which may lead to chromosome mis‑segregation, genomic instability and malignant transformation.
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