U-Blot® Histone H3 (Mono Methyl Lys4, Phospho Thr6) Rabbit pAb

Background: Histone post-translational modifications form combinatorial epigenetic codes that regulate chromatin structure and gene expression. H3K4me1T6p is a dual modification on histone H3, consisting of monomethylation at Lys4 and phosphorylation at Thr6. H3K4me1 is a canonical epigenetic marker of active and poised enhancers, while H3T6p is a mitosis-related phosphorylation primarily catalyzed by PKC kinases. This combined mark dynamically regulates chromatin state during cell cycle progression. During mitosis, T6 phosphorylation occurs on H3K4me1-modified histones, remodeling chromatin protein binding and facilitating chromosome condensation, while preserving the H3K4me1 epigenetic signature. Abnormal regulation of H3K4me1T6p affects mitotic chromatin remodeling and epigenetic inheritance, closely associated with genomic instability.