info@ucallmlabs.com
Introduction
Protein acetylation is a common post‑translational modification (PTM) characterized by the addition of acetyl groups to lysine residues or protein N‑termini. Regulated by acetyltransferases and deacetylases, acetylation plays important roles in chromatin remodeling, gene expression, protein function regulation, and cellular metabolism. Dysregulated acetylation is associated with various diseases, making acetylation analysis valuable for understanding disease mechanisms and identifying potential therapeutic targets.
Products Solutions
We offer acetylation‑specific antibodies, enrichment reagents, and labeled antibodies (FITC, HRP, and Biotin) for acetylation detection and enrichment, complemented by protein arrays for high‑throughput functional analysis.
- Broad target coverage
- High specificity and reliability
- Efficient acetylation enrichment
- High‑throughput functional profiling
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Acetyllysine Rabbit pAb | WT9011 |
| Rabbit pAb | Pan‑Acetyllysine Rabbit pAb | WT9179 |
| Rabbit mAb | Pan‑Acetyllysine Rabbit mAb | WT9012 |
| Rabbit mAb | Pan‑Acetyllysine Rabbit mAb | WR5298 |
| Rabbit mAb | Pan‑Acetyllysine Rabbit mAb | WT9504R |
| Mouse mAb | Pan‑Acetyllysine Mouse mAb | WT9180 |
| MultiPTM | Acetyl Lysine MultiPTM Rabbit Monoclonal Antibody mix | WT9012M |
| Agarose Conjugated | Acetyl Lysine Specific Antibody Conjugated Agarose Beads | WT9150B |
| FITC Conjugated | Pan‑Acetyllysine Rabbit pAb, FITC | WT9183F |
| HRP Conjugated | Pan‑Acetyl Lysine Rabbit pAb, HRP | WT9186P |
| Biotin Conjugated | Pan‑Acetyllysine Rabbit pAb, Biotin | WT9192C |
| Motif Magnetic Immunoaffinity Kit | Acetyl‑Lysine Motif (Ace‑K) Magnetic Immunoaffinity Kit | WT910K |
| Motif Kit | Acetyl‑Lysine Motif (Ace‑K) Kit | WT909K |
| Array | Human Protein Acetylation Array G507 | WT9601A‑G507‑4 |
| Array | Human Protein Acetylation Array G507 | WT9601A‑G507‑8 |
| Array | Human Protein Acetylation Array G493 | WT9601A‑G493‑4 |
| Array | Human Protein Acetylation Array G493 | WT9601A‑G493‑8 |
| Array | Human Protein Acetylation Array G8000 | WT9601A‑G8000‑4 |
| Array | Human Protein Acetylation Array G8000 | WT9601A‑G8000‑8 |
| Kit | Acylation Modification Antibody Combo Kit | WT931K |
| Kit | Acylation Antibody Sampler Kit | WT901K |
Research Areas
- Epigenetic Regulation
- DNA damage repair
- Cancer research
- Metabolism
References
- Shvedunova M, Akhtar A. Modulation of cellular processes by histone and non‑histone protein acetylation. Nat Rev Mol Cell Biol. 2022;23(5):329‑349.
- Li AM, He B, Karagiannis D, et al. Serine starvation silences estrogen receptor signaling through histone hypoacetylation. Proc Natl Acad Sci U S A. 2023;120(38):e2302489120.
- Popova LV, Nagarajan P, Lovejoy CM, et al. Epigenetic regulation of nuclear lamina‑associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021;49(21):12136‑12151.
- Jiang W, Wang S, Xiao M, et al. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell. 2011;43(1):33‑44.