info@ucallmlabs.com
Introduction
Lysine butyrylation (Kbu) is a lysine acylation modification driven by butyrate, a short‑chain fatty acid produced by microbial fermentation in the gut. The identification of Kbu has provided new insights into how gut microbial‑driven metabolites regulate host protein function and epigenetic process. Kbu has been detected on histone and non‑histone proteins, where it contributes to the regulation of gene expression, cellular metabolism, and physiological functions. Growing evidence has linked Kbu to biological processes including cancer progression, inflammation, metabolic disorders, and host‑microbiome interactions.
Products Solutions
We provide reliable antibody tools for detecting Kbu and studying its biological functions.
- BSA/Azide‑free options
- Pan‑Kbu modification detection
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Mouse mAb | Pan‑Butyryllysine Mouse mAb | WT9042 |
| Rabbit mAb | Pan‑Butyryllysine Rabbit mAb | WT9043R |
| Rabbit mAb | Pan‑Butyryllysine Rabbit mAb‑BSA and Azide free | WT9044R |
| Rabbit mAb | Pan‑Butyryllysine Rabbit mAb | WT9506R |
| Rabbit pAb | Pan‑Butyryllysine Rabbit pAb | WT9045 |
Research Areas
- Spermatogenesis and development regulation
- Cancer biology
- Chromatin regulation and gene expression
References
- Goudarzi A, Zhang D, Huang H, et al. Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol Cell. 2016;62(2):169‑180.
- Liu R, Wu J, Guo H, Yao W, Li S, Lu Y, Jia Y, Liang X, Tang J, Zhang H. Post‑translational modifications of histones: Mechanisms, biological functions, and therapeutic targets. MedComm (2020). 2023 May 20;4(3):e292.
- He Y, Zheng CC, Yang J, et al. Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance. Cell Discov. 2023;9(1):74.