info@ucallmlabs.com
Introduction
Crotonylation is a recently identified lysine acylation modification that was first recognized as a histone modification in 2011. This modification is characterized by the addition of a crotonyl group to lysine residues. Enriched in transcriptionally active chromatin, histone crotonylation regulates chromatin organization and gene expression. Growing evidence indicates that crotonylation participates in diverse biological processes, including cell differentiation, reproductive development, and cellular regulation. The identification of crotonylation provides new insights into the epigenetic mechanisms underlying gene expression and biological functions.
Products Solutions
Our crotonylation products provide reliable tools for the detection and enrichment of crotonylation‑modified proteins, supporting studies of protein crotonylation and its biological functions.
- High‑sensitive detection
- Broad reactivity across crotonylation‑modified proteins
- Reliable immunoaffinity enrichment
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Crotonyllysine Rabbit pAb | WT9005 |
| Rabbit mAb | Pan‑Crotonyllysine Rabbit mAb | WT9006 |
| Mouse mAb | Pan‑Crotonyllysine Mouse mAb | WT9170 |
| MultiPTM | Crotonyllysine MultiPTM Rabbit Monoclonal Antibody Mix | WT9006M |
| Agarose Conjugated | Crotonyllysine Specific Antibody Conjugated Agarose Beads | WT9161B |
Research Areas
- Reproductive biology
- Cell differentiation
- Chromatin organization
- Gene transcription
References
- Tan M, Luo H, Lee S, et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell. 2011;146(6):1016‑1028.
- Yuan S, Yan Y, Liang Y, et al. The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos. Adv Sci (Weinh). 2026;13(36):e75143.
- Wang YF, Wan YT, Qi QR, et al. Echs1‑mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryos. Nat Commun. 2025;16(1):5630.
- Yuan S, Yan Y, Liang Y, et al. The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos. Adv Sci (Weinh). 2026;13(36):e75143.