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Fumarylation
Introduction
Lysine fumarylation (Kfu) is a recently identified PTM first characterized in Escherichia coli. The fumaryl group is installed onto lysine residues by SpeG and removed by CobB. Derived from fumarate, a key metabolite of the TCA cycle, Kfu participates in cellular stress adaptation, including temperature and oxidative stress responses.
Products Solutions
Our Kfu products include pan‑fumaryllysine antibodies, a MultiPTM Rabbit Monoclonal Antibody Mix, and fumaryllysine‑specific agarose beads, providing flexible tools for Kfu modification detection and enrichment.
- Multiple monoclonal antibodies mix for enhanced Kfu recognition
- Kfu‑specific detection
- Targeted Kfu enrichment
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Fumaryllysine Rabbit pAb | WT9034 |
| Rabbit mAb | Pan‑Fumaryllysine Rabbit mAb | WT9035 |
| MultiPTM | Fumaryllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9035M |
| Agarose Conjugated | Fumaryllysine Specific Antibody Conjugated Agarose Beads | WT9157B |
Research Areas
- Stress responses
References
- Chen C, Zhang X, Bai X, et al. Discovery and Enzymatic Regulation of Lysine Fumarylation, a Post‑Translational Modification in Bacteria. J Am Chem Soc. 2026;148(15):16502‑16514.