info@ucallmlabs.com
Introduction
Itaconate is an immunometabolite that drives two distinct protein modifications: cysteine itaconation (S‑itaconation) and lysine itaconylation (K‑itaconylation). S‑itaconation was first characterized in 2018 as an electrophilic cysteine modification involved in inflammatory regulation. In 2023, K‑itaconylation was identified as a novel lysine acylation modification. Despite sharing the same metabolic origin, these modifications are mediated through distinct chemical mechanisms and contribute to different biological processes.
| Feature | S‑Itaconation | K‑Itaconylation |
|---|---|---|
| Modified Residue | Cysteine (Cys) | Lysine (Lys) |
| Precursor / Donor | Itaconate | Itaconyl‑CoA |
| Chemical Mechanism | Cysteine thiol modification | Lysine acylation |
| Reversibility | Generally stable | Not fully characterized |
| Biological Functions | Inflammatory regulation, antibacterial immunity | Not fully characterized |
Products Soutions
Our antibodies enable detection of both cysteine itaconation (S‑itaconation) and lysine itaconylation (K‑itaconylation), providing tools for studying distinct itaconate‑mediated protein modifications.
- Cysteine itaconation detection
- Lysine itaconylation detection
- Specific enrichment of K‑itaconylated proteins
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | PanItaconylCysteine Rabbit pAb | WT9030 |
| Rabbit mAb | PanItaconylCysteine Rabbit mAb | WT9031 |
| MultiPTM | ItaconylCysteine MultiPTM Rabbit Monoclonal Antibody mix | WT9031M |
| Agarose Conjugated | Itaconyllysine Specific Antibody Conjugated Agarose Beads | WT9160B |
Research Areas
- Inflammatory regulation
References
- Mills EL, Ryan DG, Prag HA, et al. Itaconate is an anti‑inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018;556(7699):113‑117.
- Liu D, Xiao W, Li H, et al. Discovery of Itaconate‑Mediated Lysine Acylation. J Am Chem Soc. 2023;145(23):12673‑12681.