info@ucallmlabs.com
Introduction
Lactylation is a recently identified lysine post‑translational modification (PTM) driven by cellular lactate metabolism. By modifying lysine residues, lactylation serves as a molecular link between cellular metabolism and protein regulation. Lactylation has been implicated in diverse biological processes, including gene expression, chromatin remodeling, immune regulation, and inflammatory responses. Emerging evidence suggests that dysregulated lactylation contributes to the development of various diseases, including cancer, cardiovascular disorders, and neurological diseases.
Products Solutions
Our lactylation product portfolio includes L‑lactylation‑specific antibodies, motif enrichment reagents, and human protein lactylation arrays, supporting sensitive detection, efficient enrichment, and high‑throughput lactylation profiling.
- Sensitive detection of L‑Lactylated proteins
- High‑specificity L‑Lactyllysine antibodies
- Efficient L‑Lactyllysine motif enrichment
- High‑throughput lactylation profiling with protein arrays
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑L‑Lactyllysine Rabbit pAb | WT9001 |
| Rabbit mAb | Pan‑L‑Lactyllysine Rabbit mAb | WT9002 |
| Rabbit mAb | Pan‑L‑Lactyllysine Rabbit mAb | WT9168R |
| Rabbit pAb | Pan‑L‑Lactyllysine Rabbit pAb‑BSA and Azide free | WT9125 |
| Rabbit mAb | Pan‑L‑Lactyllysine Rabbit mAb | WT9511R |
| Rabbit pAb | Pan‑D‑Lactyllysine Rabbit pAb | WT9003 |
| Rabbit mAb | Pan‑D‑Lactyllysine Rabbit mAb | WT9004 |
| MultiPTM | L‑Lactyllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9002M |
| MultiPTM | D‑lactyllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9004M |
| Motif (L‑lac‑K) Kit | L‑Lactyl‑Lysine Motif (L‑lac‑K) Kit | WT903K |
| Motif (L‑Lac‑K) Magnetic Immunoaffinity Kit | L‑Lactyl‑Lysine Motif (L‑Lac‑K) Magnetic Immunoaffinity Kit | WT904K |
| Motif (D‑Lac‑K) Kit | D‑Lactyl‑Lysine Motif (D‑Lac‑K) Kit | WT917K |
| Agarose Conjugated | L‑Lactyl Lysine Specific Antibody Conjugated Agarose Beads | WT9153B |
| Agarose Conjugated | D‑Lactyl Lysine Specific Antibody Conjugated Agarose Beads | WT9162B |
| Array | Human Protein Lactylation Array G507 | WT9610A‑G507‑4 |
| Array | Human Protein Lactylation Array G507 | WT9610A‑G507‑8 |
| Array | Human Protein Lactylation Array G493 | WT9610A‑G493‑4 |
| Array | Human Protein Lactylation Array G493 | WT9610A‑G493‑8 |
| Array | Human Protein Lactylation Array G8000 | WT9610A‑G8000‑4 |
| Array | Human Protein Lactylation Array G8000 | WT9610A‑G8000‑8 |
Research Areas
- Metabolic regulation
- Gene expression and chromatin remodeling
- Inflammation and immune responses
- Tumor microenvironment
References
- Zhang D, Tang Z, Huang H, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574(7779):575‑580.
- Li H, Liu C, Li R, et al. AARS1 and AARS2 sense L‑lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024;634(8036):1229‑1237.
- Raychaudhuri D, Singh P, Chakraborty B, et al. Histone lactylation drives CD8+ T cell metabolism and function. Nat Immunol. 2024;25(11):2140‑2151.
- Li C, Liu Z, Kong D, Li Z, Li L. Lactylation: a novel driver of drug resistance in the tumor microenvironment. Cancer Drug Resist. 2025;8:39.