info@ucallmlabs.com
Introduction
Lysine malonylation (Kmal) is a reversible post‑translational modification mediated by malonyl‑CoA. The introduction of malonyl groups converts lysine residues from a positive to a negative charge, potentially reshaping protein conformation and molecular interactions. Kmal is widely involved in metabolic regulation, particularly in fatty acid metabolism, mitochondrial function, and glycolysis.
Products Solutions
We provide specific tools for Kmal detection and enrichment, including multi‑epitope antibodies for improved modification recognition.
- Multi‑antibody strategy for enhanced Kmal detection
- Flexible antibody options
- Kmal‑specific enrichment
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Malonyllysine Rabbit pAb | WT9020 |
| Rabbit mAb | Pan‑Malonyllysine Rabbit mAb | WT9021 |
| Mouse mAb | Pan‑Malonyllysine Mouse mAb | WT9173 |
| MultiPTM | Malonyllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9021M |
| Motif (Mal‑K) Kit | Malonyl‑Lysine Motif (Mal‑K) Kit | WT915K |
| Agarose Conjugated | Malonyl Lysine Specific Antibody Conjugated Agarose Beads | WT9164B |
Research Areas
- Immune regulation
- Cancer biology
- Metabolic disorders
References
- Zou L, Yang Y, Wang Z, et al. Lysine Malonylation and Its Links to Metabolism and Diseases. Aging Dis. 2023;14(1):84‑98. Published 2023 Feb 1.
- Nishida Y, Rardin MJ, Carrico C, et al. SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target. Mol Cell. 2015;59(2):321‑332.
- Peng C, Lu Z, Xie Z, et al. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics. 2011;10(12):M111.012658.