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Introduction
Protein methylation refers to the covalent modification of lysine and arginine residues by the addition of methyl groups derived from S‑adenosylmethionine (SAM). Lysine methylation, including mono‑, di‑, and trimethylation (Kme1, Kme2, and Kme3), serves as a key epigenetic mechanism controlling chromatin organization and gene expression. Analysis of protein methylation provides insights into epigenetic regulation and the molecular mechanisms underlying cellular identify and function.
Products Solutions
Our methylation products support the investigation of methylation patterns and epigenetic regulation, providing reliable tools for methylation detection, enrichment, and analysis.
- High specificity
- Methylation state recognition
- Efficient enrichment
- Flexible labeling formats
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit mAb | Pan‑Di‑Methyllysine Rabbit mAb‑BSA and Azide free | WT9049R |
| Rabbit mAb | Pan‑Di‑Methyllysine Rabbit mAb | WT9144 |
| Rabbit pAb | Pan‑Di‑Methyllysine Rabbit pAb | WT9050 |
| Rabbit pAb | Pan‑Mono/Di‑Methyllysine Rabbit pAb | WT9199 |
| Rabbit mAb | Pan‑Asymmetric Di‑Methyl Arginine Rabbit mAb | WT9041R |
| Rabbit mAb | Pan‑Symmetric Di‑Methyl Arginine Rabbit mAb | WT9111R |
| Rabbit pAb | Pan‑Symmetric Di‑Methyl Arginine Rabbit pAb | WT9112 |
| Rabbit pAb | Pan‑Symmetric Di‑Methyl Arginine Rabbit pAb | WT9112 |
| Rabbit mAb | Pan‑Symmetric Di‑Methyl Arginine Rabbit mAb | WT9509 |
| Rabbit pAb | Pan‑Tri‑Methyllysine Rabbit pAb | WT9113 |
| Rabbit pAb | Pan‑Tri‑Methyllysine Rabbit pAb | WT9182 |
| Agarose Conjugated | Tri‑Methyl Lysine Specific Antibody Conjugated Agarose Beads | WT9167B |
| Agarose Conjugated | Methyl Lysine Specific Antibody Conjugated Agarose Beads | WT9168B |
| Agarose Conjugated | Symmetric Di‑Methyl Arginine Specific Antibody Conjugated Agarose Beads | WT9159B |
| FITC Conjugated | Pan‑Tri‑Methyllysine Rabbit pAb, FITC | WT9184F |
| FITC Conjugated | Pan‑Methyllysine Rabbit pAb, FITC | WT9185F |
| HRP Conjugated | Pan‑Methyllysine Rabbit pAb, HRP | WT9187P |
| HRP Conjugated | Pan‑Tri‑Methyllysine Rabbit pAb, HRP | WT9191P |
| Biotin Conjugated | Pan‑Methyllysine Rabbit pAb, Biotin | WT9196C |
| Biotin Conjugated | Pan‑Tri‑Methyllysine Rabbit pAb, Biotin | WT9197C |
Research Areas
- Epigenetic regulation
- Chromatin remodeling
- Transcriptional regulation
- Cancer research
References
- Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012;13(5):343‑357.
- Kubo N, Chen PB, Hu R, Ye Z, Sasaki H, Ren B. H3K4me1 facilitates promoter‑enhancer interactions and gene activation during embryonic stem cell differentiation. Mol Cell. 2024;84(9):1742‑1752.e5.
- Chuikov S, Kurash JK, Wilson JR, et al. Regulation of p53 activity through lysine methylation. Nature. 2004;432(7015):353‑360.
- Chen X, Huang MF, Fan DM, et al. CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development. Nucleic Acids Res. 2024;52(12):6811‑6829.