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Introduction
Lysine propionylation (Kpr) is a propionyl‑CoA‑dependent lysine acylation modification. It covalently links propionyl groups to lysine residues of target proteins. Regulated by cellular metabolism, Kpr mirrors intracellular metabolic status and modulates functions of histones and non‑histone proteins. A growing body of evidence shows that Kpr regulates chromatin dynamics, transcription and core metabolic processes.
Products Solutions
Our Kpr products provide reliable tools for the detection and enrichment of Kpr. In particular, the Multi‑Epitope Monoclonal Antibody Mix combines multiple Kpr‑specific rabbit monoclonal antibodies to achieve broader epitope recognition and improved detection capability for Kpr‑modified proteins.
- Multi‑epitope rabbit monoclonal antibody mix
- Flexible antibody formats
- Efficient Kpr modification enrichment
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Propionyllysine Rabbit pAb | WT9018 |
| Rabbit mAb | Pan‑Propionyllysine Rabbit mAb | WT9019 |
| Mouse mAb | Pan‑Propionyllysine Mouse mAb | WT9172 |
| MultiPTM | Propionyllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9019M |
| Motif (Prop‑K) Kit | Propionyl‑Lysine Motif (Prop‑K) Kit | WT914K |
| Agarose Conjugated | Propionyl Lysine Specific Antibody Conjugated Agarose Beads | WT9165B |
Research Areas
- Chromatin regulation and gene expression
- Metabolic regulation
- Cellular stress response
- Microbial metabolism
- Plant physiology and photosynthesis
References
- Chen Y, Sprung R, Tang Y, et al. Lysine propionylation and butyrylation are novel post‑translational modifications in histones. Mol Cell Proteomics. 2007;6(5):812‑819.
- Liu Z, Wang X, Li L. Lysine Propionylation as a Metabolically Coupled PTM: Mechanisms, Functional Consequences, and Therapeutic Potentials. Int J Mol Sci. 2026;27(7):2937.
- Kebede AF, Nieborak A, Shahidian LZ, et al. Histone propionylation is a mark of active chromatin. Nat Struct Mol Biol. 2017;24(12):1048‑1056.
- Yang M, Huang H, Ge F. Lysine Propionylation is a Widespread Post‑Translational Modification Involved in Regulation of Photosynthesis and Metabolism in Cyanobacteria. Int J Mol Sci. 2019;20(19):4792.