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Spatial Cell Atlas
Building a Molecular Atlas of the Nervous System Decoding Cellular Diversity, State and Spatial Organization at Molecular Resolution
The nervous system comprises diverse neuronal and glial populations organized into highly specialized cellular networks that support information processing, homeostasis, plasticity, and responses to disease.
Understanding this complexity requires molecularly resolved characterization of cells across multiple biological dimensions:
- Cellular identity - defining distinct neuronal and glial populations
- Developmental state - tracking neural lineage progression and maturation
- Functional state - revealing activity, stress, and disease-associated transitions
- Spatial organization - mapping cellular distribution and interactions within brain regions
From Cell Identity to Functional State, Spatial Organization, and Cellular Interactions - build a molecularly resolved view of the nervous system.

1. Neural Cell Atlas Antibody Panel
From Cell Identity to Functional State Characterization
Integrated antibody solutions for neural cell identity, lineage, subtype, state, function, and disease-associated phenotypes.
A comprehensive neural cell profiling strategy combines validated molecular markers with multiplex imaging and spatial analysis to resolve cellular diversity, phenotypic states, tissue organization, and functional changes across the nervous system.
2. Integrated Neural Cell Profiling Strategy
Decoding Brain Complexity Across Multiple Biological Dimensions
| Research Dimension | Biological Question | Molecular Readout | Representative Targets |
|---|---|---|---|
| 1. Cellular Identity | Which neural cell types and subtypes are present? | Define neuronal and glial composition through cell-type specific markers | Neurons: NeuN, MAP2, Tubb3, CUX1, SATB2, CTIP2 Astrocytes: GFAP, ALDH11L1, S100B Microglia: IBA1, TMEM119, P2RY12 Oligodendrocytes: OLIG2, SOX10, MBP |
| 2. Cellular State & Phenotype | How do cells respond, adapt, or become dysfunctional? | Characterize activation, stress, aging, inflammatory and pathological states | Microglia activation: C1q, ApoE, CD68, TREM2 Astrocyte reactivity: GFAP, AQP4, S100B Neuronal stress: c-Fos, ATF3, HIF-1α Degeneration: pTau, Aβ, TDP43 |
| 3. Cell-Cell Communication | How do neural cells interact and regulate circuits? | Analyze synaptic connectivity, neurotransmission and signaling networks | Synapse: PSD95, Synaptophysin, Homer1, Gephyrin Neurotransmission: vGLUT1/2, GAD67, ChAT, TH Cell signaling: BDNF, CREB, mTOR |
| 4. Spatial Organization & Architecture | Where are specific cell populations located within neural circuits? | Map cellular distribution, tissue organization and microenvironment niches | Spatial IF / Multiplex Imaging: Cortical layers: CUX1, SATB2, CTIP2, TLE4 Brain regions: Hypothalamic peptides, hippocampal markers Cell neighborhood profiling |
| 5. Functional Network Output | How do molecular changes influence neural activity and behavior? | Link molecular signatures to neuronal function and circuit activity | Activity markers: c-Fos, Arc, EGR1 Plasticity: CREB, CaMKII, BDNF Pathway analysis: MAPK, PI3K/AKT, mTOR |

We provide validated antibody solutions for resolving neural cell identity, cellular states, cell-cell interactions, spatial organization, and functional activity — enabling molecularly resolved characterization of brain structure, cellular networks, and disease-associated changes.


| Fluorescence Target | Product Name | Catalog No. | Reactivity | Applications | Biological Interpretation |
|---|---|---|---|---|---|
| NeuN (RBFOX 3) 488 nm | U-Blot® NeuN Rabbit mAb | WR4580 | Human, Mouse, Rat | WB, IHC, IF, ELISA | Identifies mature neurons and evaluates neuronal survival and neurodegeneration after hemorrhagic injury. |
| GFAP 594 nm | U-Blot® GFAP Rabbit mAb | WR4151 | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA | Detects reactive astrocytes and measures astrogliosis surrounding the hematoma and injured tissue. |
| IBA1 440 nm | U-Blot® Iba1 Rabbit mAb | WR4144 | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA | Assesses microglial activation, neuroinflammatory responses, and immune-cell accumulation after ICH. |
| CD31 555 nm | U-Blot® CD31 Rabbit mAb | WR4185 | Human, Mouse, Rat | WB, IHC, IF, ELISA | Labels cerebral blood vessels to evaluate vascular integrity, angiogenesis, and blood-brain barrier alterations. |
| MAP2 647 nm | U-Blot® MAP2 Rabbit mAb | WR5051 | Human, Mouse, Rat | WB, IHC, IF, ELISA | Detects dendritic architecture and assesses dendritic degeneration following ischemic injury. |
3. Featured Products
| Catalog No. | Product Name | Reactivity | Validated Applications |
|---|---|---|---|
| WR4811 | U-Blot® SOX-2 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR4797 | U-Blot® Musashi-1 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR4399 | U-Blot® PAX6 Rabbit mAb | Human, Mouse | WB, IHC, IF, ELISA |
| WR4338 | U-Blot® β3 Tubulin Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR4750 | U-Blot® LHFLP5 Rabbit mAb | Human, Mouse, Rat | WB |
| WR4578 | U-Blot® MAP2 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR8094 | U-Blot® PGP 9.5 Rabbit mAb (Ready to Use) | Human, Mouse, Rat | IHC |
| WR4197 | U-Blot® PGP9.5 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR4916 | U-Blot® Neurofilament (NF-L) Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR8087 | U-Blot® Neurofilament(NF-L) Rabbit mAb (Ready to Use) | Human | IHC |
| WR5210 | U-Blot® NF-M (Phospho Ser614/Ser619) Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR4138 | U-Blot® Neurofilament heavy polypeptide Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR5113 | U-Blot® HuD/HuC Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR4475 | U-Blot® TBR1 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR4503 | U-Blot® SATB2 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR4403 | U-Blot® Ctip2 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR5171 | U-Blot® FoxP2 Rabbit mAb | Human, Mouse, Rat | WB, IF, IP, ELISA |
| WR4938 | U-Blot® FoxA2 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, IP, ELISA |
| WR8089 | U-Blot® OLIG2 Rabbit mAb (Ready to Use) | Human, Mouse | IHC |
| WR4617 | U-Blot® OLIG2 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR4425 | U-Blot® SOX10 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA, IP |
| WR8105 | U-Blot® SOX9 Rabbit mAb (Ready to Use) | Human, Mouse, Rat, Bovine | IHC |
| WR4149 | U-Blot® SOX9 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR5369 | U-Blot® MYT1 Rabbit mAb | Human, Mouse, Rat | WB, IHC, IF, ELISA |
| WR8119 | U-Blot® TTF-1 Rabbit mAb (Ready) | Human, Mouse, Rat | IHC |
