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Introduction
Succinylation is an acylation modification involving the covalent attachment of a succinyl group to lysine residues. Compared with other lysine acylations, succinylation markedly alters the physicochemical properties of proteins, thereby influencing protein structure and function. Widely distributed in both histone and non‑histone proteins, succinylation plays important roles in cellular metabolism, epigenetic regulation, and signal transduction.
Products Solutions
Our succinylation products include Pan‑succinyllysine antibodies and immunoaffinity reagents for the detection and enrichment of succinylated proteins. Notably, the MultiPTM Rabbit Monoclonal Antibody Mix combines multiple monoclonal antibodies with complementary recognition properties, providing enhanced detection performance for protein succinylation.
- MultiPTM Antibody Mix for enhanced detection
- Pan‑succinyllysine antibody reagents
- Immunoaffinity enrichment reagents
- Multiple antibody formats
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Succinyllysine Rabbit pAb | WT9009 |
| Rabbit mAb | Pan‑Succinyllysine Rabbit mAb | WT9010 |
| Mouse mAb | Pan Succinyllysine Mouse mAb | WT9169 |
| MultiPTM | Succinyllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9010M |
| Motif (Succ‑K) Kit | Succinyl‑Lysine Motif (Succ‑K) Kit | WT907K |
| Motif (Succ‑K) Magnetic Immunoaffinity Kit | Succinyl‑Lysine Motif (Succ‑K) Magnetic Immunoaffinity Kit | WT908K |
| Agarose Conjugated | Succinyllysine Specific Antibody Conjugated Agarose Beads | WT9155B |
Research Areas
- Mitochondrial metabolism
- Cellular stress response
- Inflammatory and immunity
- Disease biology
References
- Zhang Z, Tan M, Xie Z, Dai L, Chen Y, Zhao Y. Identification of lysine succinylation as a new post‑translational modification. Nat Chem Biol. 2011;7(1):58‑63.
- Du J, Zhou Y, Su X, et al. Sirt5 is a NAD‑dependent protein lysine demalonylase and desuccinylase. Science. 2011;334(6057):806‑809.
- Hirschey MD, Zhao Y. Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. Mol Cell Proteomics. 2015;14(9):2308‑2315.
- Zhou J, Tian X, Zhou Y, Tan N, Chen B. Succinylation: novel molecular mechanisms and prospects for targeted therapy in liver diseases. Front Mol Biosci. 2026;13:1768199.