SUMOylation

Introduction

SUMOylation is a reversible post‑translational modification that regulates protein function through the covalent attachment of small ubiquitin‑like modifier (SUMO) proteins to specific lysine residues in proteins. This process is mediated by SUMO‑related enzymes and regulates diverse cellular process, including protein stability, nuclear transport, transcription, DNA repair, and stress response. Emerging studies have revealed the critical role of SUMOylation in maintaining cellular homeostasis and regulating complex biological processes, making it an important target for understanding protein regulation and cellular function.

Products Solutions

Our SUMOylation products provide reliable tools for detecting and enriching SUMO‑modified proteins, enabling studies of SUMOylation patterns and biological functions.

• Sensitive detection of SUMOylated proteins
• Efficient K‑GG motif enrichment
• Advanced modification profiling
• High‑specificity SUMO antibody recognition

Research Areas

• Protein function and interaction
• Nuclear transport and localization
• Transcription and Chromatin regulation
• Cellular stress and immune response

References

1. Fan Y, Li X, Zhang L, et al. SUMOylation in Viral Replication and Antiviral Defense. Adv Sci (Weinh). 2022;9(7):e2104126.
2. Chen YD, Liu JY, Lu YM, et al. Functional roles of C/EBPα and SUMOmodification in lung development. Int J Mol Med. 2017;40(4):1037‑1046.
3. Zhu X, Qiu C, Wang Y, et al. FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proc Natl Acad Sci U S A. 2022;119(26):e2202631119.
4. Sahin U, de Thé H, Lallemand‑Breitenbach V. Sumoylation in Physiology, Pathology and Therapy. Cells. 2022;11(5):814.