info@ucallmlabs.com
Introduction
Ubiquitination is a dynamic protein modification that determines the fate and function of target proteins through the covalent attachment of ubiquitin molecules. This process is orchestrated by a sequential enzymatic cascade involving ubiquitin‑activating enzymes (E1), ubiquitin‑conjugating enzymes (E2), and ubiquitin ligases (E3).
Beyond its classical role in proteasome‑mediated protein degradation, ubiquitination regulates diverse cellular processes, including protein degradation, trafficking, DNA damage repair, cell cycle progression, and immune responses. Dysregulated ubiquitination is implicated in multiple diseases, particularly cancer and neurodegenerative disorders, making it an important target for disease mechanism studies and therapeutic development.
Products Solutions
Our ubiquitination antibodies and reagents enable sensitive and specific detection of ubiquitin‑modified proteins, supporting studies of protein deregulation and signaling pathways.
- High specificity and sensitivity
- Ubiquitin enrichment and profiling
- Broad application compatibility
- Validated antibody performance
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Mouse mAb | Pan‑Ubiquitin Mouse mAb | WT9114R |
| Mouse mAb (NT) | Pan‑Ubiquitin Mouse mAb (NT) | WT9115 |
| Mouse mAb | Ubiquitin mouse Monoclonal Antibody | WM1190 |
| Rabbit mAb | Pan‑ubiquitin Rabbit mAb | WT9116R |
| Rabbit mAb | Pan‑Ubiquitin Rabbit mAb | WT9117R |
| Rabbit mAb | Pan‑Ubiquitin Rabbit mAb‑BSA and Azide free | WT9118R |
| Rabbit pAb | Pan‑K‑ε‑GG Rabbit pAb | WT9146 |
| Rabbit pAb | Pan‑K‑ε‑GV Rabbit pAb | WT9147 |
| Agarose Conjugated | K‑ε‑GG Specific Antibody Conjugated Agarose Beads | WT9151B |
| Agarose Conjugated | K‑ε‑GV Specific Antibody Conjugated Agarose Beads | WT9152B |
| Motif (K‑ε‑GG) Kit | Ubiquitin/SUMO Remnant Motif (K‑ε‑GG) Kit | WT905K |
| Magnetic Immunoaffinity Kit | Ubiquitin/SUMO Remnant Motif (K‑ε‑GG) Magnetic Immunoaffinity Kit | WT906K |
Research Areas
- Protein degradation and stability
- Cell signaling pathway
- DNA damage response and repair
- Immune regulation
References
- Swatek KN, Komander D. Ubiquitin modifications. Cell Res. 2016;26(4):399‑422.
- Schwertman P, Bekker‑Jensen S, Mailand N. Regulation of DNA double‑strand break repair by ubiquitin and ubiquitin‑like modifiers. Nat Rev Mol Cell Biol. 2016;17(6):379‑394.
- Cheng J, Xu L, Xuan Y, et al. Linear polyubiquitylation of Gli protein regulates its protein stability and facilitates tumor growth in colorectal cancer. Cell Death Discov. 2024;10(1):369.