info@ucallmlabs.com
Introduction
Lysine β‑hydroxybutyrylation (Kbhb) is a novel post‑translational modification mediated by the ketone body β‑hydroxybutyrate (BHB). Kbhb levels are dynamically regulated under ketogenic metabolic conditions, including fasting, ketogenic diets, and prolonged physical exercise. Emerging evidence has highlighted Kbhb as an important metabolic‑epigenetic interface that connects cellular energy status with chromatin regulation and protein function. Kbhb has demonstrated regulatory roles across diverse biological contexts, including oncology, immunomodulation, metabolic homeostasis, circadian remodeling, and developmental processes.
Products Solutions
Kbhb products provide reliable tools for the detection and enrichment of Kbhb, supporting studies of Kbhb‑mediated regulation in metabolism, epigenetics, and disease‑related research.
- Specific Kbhb recognition
- Efficient Kbhb enrichment
- Reliable detection and analysis
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit mAb | Pan‑β‑Hydroxybutyryllysine Rabbit mAb | WT9120R |
| Rabbit pAb | Pan‑β‑Hydroxybutyryllysine Rabbit pAb | WT9508 |
| Agarose Conjugated | β‑hydroxybutyryl Lysine Specific Antibody Conjugated Agarose Beads | WT9166B |
Research Areas
- Metabolic regulation and energy homeostasis
- DNA damage response and repair
- Cancer biology and tumor metabolism
- Gene expression and transcription regulation
References
- Zhou T, Cheng X, He Y, et al. Function and mechanism of histone β‑hydroxybutyrylation in health and disease. Front Immunol. 2022;13:981285.
- Xie Z, Zhang D, Chung D, et al. Metabolic Regulation of Gene Expression by Histone Lysine β‑Hydroxybutyrylation. Mol Cell. 2016;62(2):194‑206.
- Huang H, Zhang D, Weng Y, et al. The regulatory enzymes and protein substrates for the lysine β‑hydroxybutyrylation pathway. Sci Adv. 2021;7(9):eabe2771.
- Qin J, Huang X, Gou S, et al. Ketogenic diet reshapes cancer metabolism through lysine β‑hydroxybutyrylation. Nat Metab. 2024;6(8):1505‑1528.