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Application SolutionsItaconate-Mediated Modifications
Itaconate is an immunometabolite that drives two distinct protein modifications: cysteine itaconation (S-itaconation) and lysine itaconylation (K-itaconylation).
Application SolutionsProtein‑macromolecule interaction
Protein-macromolecule interactions serve as the fundamental basis for cellular signal transduction, metabolic regulation, immune responses, and gene expression, with their dysregulation frequently associated with cancer, autoimmune diseases, and neurodegenerative disorders.
Application SolutionsSpatial/proximity interaction
Spatial/proximity interaction studies aim to capture the physical proximity between spatially adjacent molecules (protein-protein, protein-nucleic acid, protein-small molecule, etc.)
Application SolutionsProtein‑small molecule interaction
Protein-small molecule interactions constitute the molecular foundation of cellular life and drug discovery, participating extensively in enzymatic catalysis, signal transduction, metabolic regulation, and gene expression.
Application SolutionsProtein‑RNA interaction-Co-IP
RNA Immunoprecipitation (RIP) is a core molecular biology technique for studying intracellular RNA‑protein interactions, serving as a powerful tool for deciphering the dynamic processes of post‑transcriptional regulatory networks and revealing the functional roles of RNA‑binding proteins (RBPs).
Application SolutionsProtein-RNA interaction-Pull‑down
Protein-RNA interactions are central mechanisms of gene expression regulation, governing RNA processing, transport, translation, and degradation.
Application SolutionsProtein-DNA interaction-Pull-down
A biotin‑labeled DNA probe is designed to target a specific genomic or regulatory region of interest.
Application SolutionsProtein-DNA interaction-ChIP (Chromatin Immunoprecipitation)
Chromatin Immunoprecipitation (ChIP) is a classical epigenetic technique for studying in vivo protein‑DNA interactions, serving as a core tool for deciphering gene expression regulatory mechanisms, transcription factor binding sites, and epigenetic modification landscapes.
Application SolutionsFRET (Fluorescence Resonance Energy Transfer)
Fluorescence Resonance Energy Transfer (FRET) is a physical process based on non-radiative dipole-dipole coupling between a donor fluorophore and an acceptor fluorophore.
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